Titin



Titin (TTN) is the largest known protein. The human TTN contains 34,350 residues. It is responsible for the passive elasticity of muscle. It has 244 domains connected by unstructured regions. The domains unfold when TTN is stretched. The images at the left and at the right correspond to one representative titin, i.e. the crystal structure of I-band fragment I67-I69 from rabbit titin (2rik).

3D Structures of Titin
Update June 2011

2wp3, 2wwm, 3knb – hTTN residues 34252-34350+obscuring-like protein 1 fragment – human

2wwk - hTTN residues 34252-34350+obscuring-like protein 1 fragment (mutant)

2rq8 – hTTN residues 12677-12765 (mutant) – NMR

1tit, 1tiu - hTTN I27 – NMR

2j8h, 2j8o, 2ill – hTTN residues 24430-24623

2nzi – hTTN residues 31854-32155

2bk8 – hTTN residues 25073-25166

1waa - hTTN residues 12801-12889

2f8v, 1ya5 - hTTN residues 1-196+telethonin

2a38 - hTTN residues 1-194

1g1c - hTTN residues 2027-2125

1bpv – hTTN A71 – NMR

3lpw – hTTN A77-A78

3lcy – hTTN A164-A165

1tki – hTTN serine kinase fragment

1nct, 1ncu – hTTN M5 – NMR

1tnm, 1tnn - hTTN M5

2y9r - hTTN M10

2rik – rTTN I67-I69 – rabbit

2rjm - rTTN I67-I69 (mutant)

3b43 - rTTN I65-I70

1h8b – rTTN residues 648-698+h α Actinin 2 EF hands 3&4

Additional Resources
See: Titin Structure & Function for additional information